Cardiovascular Changes in Decompensated Liver Cirrhosis
Keywords:
Liver cirrhosis, cardiovascular changes, decompensated cirrhosis, mean arterial pressure, heart rate, echocardiography, systemic inflammationAbstract
Liver cirrhosis is a significant health concern due to its systemic impacts, particularly on cardiovascular health. This study investigates the cardiovascular changes in patients with decompensated liver cirrhosis. Despite existing knowledge on liver cirrhosis, the precise mechanisms linking it to cardiovascular dysfunction remain inadequately understood. We conducted a cross-sectional analysis of 100 patients, divided equally into compensated and decompensated cirrhosis groups. Cardiovascular parameters, including mean arterial pressure, heart rate, and echocardiographic measures, were assessed alongside systemic inflammation markers such as CRP and bilirubin levels. Findings revealed that patients with decompensated cirrhosis had significantly higher mean arterial pressures (92 ± 10 mmHg), heart rates (85 ± 7 bpm), and left ventricular end-diastolic dimensions (50 ± 6 mm) compared to the compensated group. Additionally, ejection fractions were lower, and systemic inflammation markers were elevated in the decompensated group. These results indicate a clear association between liver dysfunction and cardiovascular impairment. The study underscores the importance of integrating cardiovascular management into the treatment protocol for liver cirrhosis patients. Future research should focus on longitudinal studies to understand the progression of these cardiovascular changes and develop targeted interventions to mitigate the cardiovascular risks associated with liver cirrhosis. These efforts could significantly improve patient outcomes and reduce the morbidity associated with this condition.