Endothelial Dysfunction in Patients with Chronic Heart Failure

Abstract

One of the main factors determining the prognosis in patients with chronic heart failure (CHF) is endothelial dysfunction. The aim of the work was to determine the antithrombogenic and vasodilating activity of the vascular wall in patients with CHF. We examined 60 people, of which 40 were the main group — patients with Q-myocardial infarction and 20 people — the comparison group. To determine

We used the "cuff" test proposed by V.P. Baluda for the antithrombogenic properties of the vessel wall. The vasomotor function of the endothelium was studied in samples with reactive hyperemia (RH) and nitroglycerin (NG). In patients with CHF, there is a decrease in the antithrombogenic and vasodilating activity of the vascular wall.

In patients with CHF IV FC, who have a long duration of CHF symptoms, FW<33%, the number of repeated adverse cardiovascular events during 6 months of follow-up is significantly higher compared to patients I, II and III CHF FC.