Scientific Novelty of Connective Tissue Biochemistry

Abstract

The article is of an overview and discussion nature, devoted to the problems of physiology and biochemistry of the connective tissue system, its interactions with the mononuclear phagocyte system (SMF) in the initiation and implementation of fibrosis processes. The view of fibrotic conditions as a "hypertrophied" nonspecific reaction of the body aimed at preserving homeostasis, in which the pathological activation of SMF cells plays an initiating role as a result of their endocytosis of biocompatible factors of various nature, coupled with non-specific activation of expression, synthesis and secretion of lysosomal enzymes and growth factors, is presented and reasoned by their own data and research results of other authors. factors.