Cytokine Profile in Patients With Rheumatoid Arthritis
Keywords:
anemiaAbstract
A possible relationship between markers of anemia, cytokine status, and left ventricular diastolic dysfunction (LVEF) was studied in patients with rheumatoid arthritis (RA). Serum levels of tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), erythropoietin (EPO), and echocardiographic markers of LVEF were studied in 85 patients. We have established the presence of an imbalance between TNF-α and IL-10, negative associations between TNF-α and EPO, as well as between TNF-α and the LDLF E/A index. Thus, anemia and LVEF in RA are associated with the influence of the proinflammatory cytokine TNF-α.