Identifying Factors and Disease Causing Drug Induced Liver Injury

Abstract

Drug-induced hepatotoxicity or drug-induced liver injury (DILI) is an acute or chronic response to a natural or manufactured compound. DILI can be classified based on clinical presentation (hepatocellular, cholestatic, or mixed), mechanism of hepatotoxicity, or histological appearance from a liver biopsy. The true incidence is difficult to estimate, yet it has become the leading cause of acute liver failure (ALF). The two mechanisms of hepatotoxicity are intrinsic, which is dose-dependent, and idiosyncratic, which is more unpredictable.