Quality of Life in Patients With Gout

Abstract

The aim is to identify factors associated with poor quality of life (QOL) in patients with gout. Materials and methods. The study included 175 patients (153 men and 22 women) with a reliable diagnosis of gout. The average age of patients was 48.0±12.3 years, the median duration of the disease was 5.7 [3.0; 12.3] years, the number of arthritis attacks per year was 3 [1; 5], the average serum uric acid level (MC) was 510±120 mmol/L. 31.4% of patients took allopurinol, 40.5% had chronic arthritis, 36.5% – subcutaneous tofuses, 23% – coronary artery disease (CHD), 76% – arterial hypertension (AH), 15.4% – type 2 diabetes mellitus (DM), 10.2% – chronic kidney disease (CKD) with glomerular filtration rate <60 ml/min, 56% – obesity, 5.1% – chronic heart failure (CHF), 9.1% – a history of vascular disasters. To identify correlations between the QOL indicators according to the EQ-5D, SF-36v1 questionnaires, the functional status (FS) according to HAQ and the clinical characteristics of the disease, as well as comorbid diseases, a correlation analysis according to Pearson and Spearman was performed. Multiple regression analysis was used to identify the factors that worsen QOL. Results and discussion. Negative correlations were found between the indicators of QOL according to SF-36 and age, duration of illness, serum MC levels, the presence of chronic arthritis, tofu, taking allopurinol, diuretics, alcohol, as well as hypertension, coronary heart disease, obesity, vascular catastrophes, CKD and CHF. After conducting a multiple regression analysis, a direct relationship was revealed between the deterioration of FS in HAQ and the female sex, old age, the number of inflamed joints and the frequency of arthritis attacks, the coefficient of multiple determination was 0.41. QOL by EQ It was inversely correlated with age, the number of inflamed joints, the frequency of arthritis attacks, taking diuretics, and obesity (R2=0,33). Reduction of the physical component of the questionnaire's health SF-36 correlated with an increase in age, the number of inflamed joints, the frequency of arthritis attacks and the presence of CKD (R2=0.3), a weak association was noted between the deterioration of the psychological component of health and the female sex, an increase in the number of inflamed joints, vascular catastrophes (R2=0.1).