Features of Juvenile Uterine Bleeding in Adolescence

Abstract

The article presents literature data from domestic and foreign authors regarding terminology, prevalence, pathogenesis and risk factors for dysfunctional uterine bleeding during puberty. According to modern views, the basis of pathogenesis is a dysfunction of the regulatory centers of the brain: the hypothalamic-pituitary system, which is a reflection of the age-related characteristics of the teenage body - the physiological immaturity of the regulatory centers and their unstable connections with the ovaries. Particular significance is attached to the defect of negative feedback of the ovaries and the hypothalamic-pituitary region of the central nervous system. Despite the increase in estrogen levels, the secretion of follicle-stimulating hormone continues without decreasing, which stimulates the growth of the follicle pool. Maintaining the secretion of follicle-stimulating hormone at a higher level than necessary inhibits the release and development of the dominant follicle from among them, and, therefore, excludes the process of ovulation with the further formation of the corpus luteum and the production of progesterone, which determines the normal rejection of the endometrium.