Changes in the Indicators of Lipid Peroxidation, Glutathione Level of Antioxidant Defense, Il–18, Il–10, and Matrilin 3 in Patients With Osteoarthritis in Combination With Type 2 Diabetes, Obesity, Arterial Hypertension

Abstract

In patients with type 2 diabetes, obesity,and arterial hypertension, the balance between lipid peroxidation processes and the glutathione level of antioxidant defense is significantly altered, which is associated with activation of IL-18 and significant IL-10 deficiency. Matrilin 3 indicators reduce in isolated osteoarthritis and its combination with arterial hypertension, increasing in the III and IV groups compared to practically healthy individuals (PHI).