Pathogenetic Significance of Endogenous Intoxication in Chronic Tubulointerstitial Nephritis in Children

Abstract

The inflammatory process in the tubulointerstitial tissue (TI) of the kidneys progresses against the background of specific and nonspecific etiologic factors. Interstitial tissue (IT) of the kidneys is the focus of pathology in tubulointerstitial kidney damage, which subsequently covers the blood, lymphatic vessels and tubules of the renal stroma. The aim of the work was an attempt to assess the state of protein metabolism in chronic tubulointerstitial nephritis (CTIN) in children, taking into account the identified pathogenetic significance of the parameters of endogenous intoxication (EI). Patients and methods: 120 children with CTIN, aged from 4 to 15 years, were examined. Taking into account the clinical variant of CTIN, all patients were divided into 2 groups: Group 1 - 52 (43%) children with a recurrent form of CTIN and Group 2 - 68 (57%) patients with latent CTIN. Among them, there were 65 boys (54%) and 55 girls (46%). All patients underwent general clinical, laboratory and instrumental examination. Results: the studies showed that in the development of rCTIN and lCTIN, an important mechanism of damage to the IT kidneys, the development of clinical symptoms and the course of the disease is both a metabolic disorder leading to structural shifts at the level of various nephron elements and to changes in the functional state of the kidneys, and instability of the cytomembranes of tubular cells. This justifies the need for combined therapy in patients with CTIN, which will help eliminate the inflammatory process, excrete endotoxins from renal tissue, stabilize cellular cytomembranes and kidney function.